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KMID : 0191120000150030273
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Journal of Korean Medical Science
2000 Volume.15 No. 3 p.273 ~ p.278
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Activated platelets induce secretion of interleukin-1beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1alpha and surface expression of intercellular adhesion molecule-1 on cultured endothelial cells
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Cha JK
Jeong MH/Bae HR/Han JY/Jeong SJ/Jin HJ/Lim YJ/Kim SH/Kim JW
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Abstract
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Atherosclerosis is an inflammatory disease. Platelet-endothelium interaction plays an important role in the pathophysiology of atherogenesis. We investigated the role of activated platelets for secretion of interleukin (IL)-1β, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α and expression of intercellular adhesion molecule (ICAM)-1 on endothelial cells. Human umbilical vein endothelial cells (HUVEC) were incubated with non-stimulated or ADP-activated platelets for 6 hr. Secretion of interleukin (IL)-1β, MCP-1 and MIP-1α and surface expression of ICAM-1 were measured by ELISA and flow cytometry. In the presence of activated platelets, the secretion of IL-1β, MCP-1, and MIP-1α and surface expression of ICAM-1 were significantly increased compared with non-activated platelets. The present study shows that activated platelets may contribute to expression of various inflammatory mediators on endothelial cells.
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